
Tab delimited abundance matrix (required)	Sample file
Tab delimited Metadata (optional)	Sample file
Tab delimited Growth rates data (optional)	Sample file
and, Tab delimited Interaction matrix (optional)	Sample file
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Overview

Web-gLV is a GUI based interactive platform for generalized Lotka-Volterra (gLV) based modeling and simulation of microbial populations. The tool can be used to generate the mathematical models with automatic estimation of parameters and use them to predict future trajectories using numerical simulations. Web-gLV also allows users to upload custom parameter files (growth rate and interaction matrix) and perform simulations.

Highlighted features include

Allows easy uploading user defined parameters (growth rates and inter microbial interaction matrix) and perform simulations
Comprehensive visual summary (using box and trend plots) of the input microbial abundance data which can be interactively used for selecting the taxa intended for simulation. Additionally, Web-gLV generates a microbial association network, which can also be used for selecting the starting taxonomic groups
A fully interactive trajectory viewer for visualizing the input time series as well as compare the predicted results. Users can selectively view a part of the trajectory for a selected set of microbes and apply a log transformation on the abundance values. The view (for the observed plot) is automatically set to the simulation time range for easy comparison. In addition, the viewer also allows performing a moving average based smoothing on the displayed trends using an input box (provided at the left bottom corner)
Starting point of simulation (‘seed’) can be interactively selected from the input dataset and can be easily modified to induce known perturbations (by editing the starting point values)

A graphical summary of the overall methodology is presented below. Please refer to the user manual and the manuscript for more details.

Disclaimer

"WEBGLV" SOFTWARE TOOL IS NOT INTENDED TO BE USED FOR TREATING OR DIAGNOSING HUMAN SUBJECTS.

"WEBGLV" or any documents available from this server ARE PROVIDED AS IS WITHOUT ANY WARRANTY OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, INCLUDING, BUT NOT LIMITED TO, ANY IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND FREEDOM FROM INFRINGEMENT, OR THAT "WEBGLV" or any documents available from this server WILL BE ERROR FREE.

In no event will the authors, their employers or any of the lab/office members be liable for any damages, including but not limited to direct, indirect, special or consequential damages, arising out of, resulting from, or in any way connected with the use of "WEBGLV" or documents available from this server.

The authors will try their best to maintain the privacy and confidentiality of the uploaded user data and will not use the data for any work directly or indirectly except for software debugging purpose.

Web-gLV

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Time series data of market shares by three competitors (reference)
Time series gut microbiome data for (reference)
Time series human (female) gut microbiome data (reference)